Researcher dedicated to tumour-suppressing genes

Hypothesis: the research page. One researcher, two researcher, three researcher, four. Five researcher, six researcher, seven researcher, more!

This is dedicated to our former chairman Dr. Mahmoud Rohani

miR-105 Inhibits Prostate Tumour Growth by Suppressing CDK6 Levels

A significant role for micro (mi)RNA in the regulation of gene expression in tumours has been recently established. In order to further understand how miRNA expression may contribute to prostate tumour growth and progression, we evaluated expression of miRNA in two invasive prostate tumour lines, PC3 and DU145, and compared it to that in normal prostate epithelial cells. Although a number of mi...

Bioinformatic identification of genes suppressing genome instability.

Unbiased forward genetic screens for mutations causing increased gross chromosomal rearrangement (GCR) rates in Saccharomyces cerevisiae are hampered by the difficulty in reliably using qualitative GCR assays to detect mutants with small but significantly increased GCR rates. We therefore developed a bioinformatic procedure using genome-wide functional genomics screens to identify and prioritiz...

Tumour-To-Tumour Metastasis

With the exception of metastatic involvement of adenomas of endocrine glands, metastasis of one primary tumour to another independent neoplasm is a rare occurrence. This paper records two such examples.